Localization of Surface Immunogenic Protein on Group B Streptococcus

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Localization of surface immunogenic protein on group B streptococcus.

The localization and accessibility of the group B streptococcus (GBS) surface immunogenic protein (Sip) at the surface of intact GBS cells were studied by flow cytometric assay and immunogold electron microscopy. Antibodies present in pooled sera collected from mice after immunization with purified recombinant Sip efficiently recognized native Sip at the surfaces of the different GBS strains te...

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The surface protein HvgA mediates group B streptococcus hypervirulence and meningeal tropism in neonates

Streptococcus agalactiae (group B streptococcus; GBS) is a normal constituent of the intestinal microflora and the major cause of human neonatal meningitis. A single clone, GBS ST-17, is strongly associated with a deadly form of the infection called late-onset disease (LOD), which is characterized by meningitis in infants after the first week of life. The pathophysiology of LOD remains poorly u...

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The main aim of this study was to demonstrate that the surface immunogenic protein (Sip) of the aquatic pathogen Streptococcus agalactiae is a potential candidate for vaccine development for Oreochromis niloticus. In this study, a Sip was identified. Alignment analysis indicated that the Sip protein was highly homologous with Sip proteins from other S. agalactiae isolated from humans (99%). SDS...

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9 Group B Streptococcus Meningitis

9.1 Introduction Streptococcus agalactiae (Group B Streptococcus, GBS) is a Gram-positive encapsulated bacterium possessing an array of virulence factors that render it capable of producing serious disease in susceptible hosts, in particular the human newborn (Maisey et al., 2008a). Notably, GBS is the leading cause of meningitis in the neonatal period (Brouwer et al., 2010; Thigpen et al., 201...

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ژورنال

عنوان ژورنال: Infection and Immunity

سال: 2001

ISSN: 0019-9567,1098-5522

DOI: 10.1128/iai.69.8.5162-5165.2001